It depends on your individual.  Consider the questions below to help make a decision.

Can they or will they provide childproof rooms ?

Do they have physically handicapped rooms available or those designed to assist elderly guests ?

Will they provide smoking or nonsmoking rooms upon request ?

What types of beds and bedding arrangements are available ?

Are they equipped with any special bathroom amenities such as Roman tubs, whirlpool baths or bidets ?

Can they guarantee adjoining or connecting rooms for families who want to be close together ?

Are there any rooms set up for business travelers, with large desks, data ports and faxes ?

How about rooms with kitchenettes ?   If so, determine what they consider a kitchenette. It can vary from a wet-bar with sink, to a small complete kitchen with the cooking utensils.  Since you’ll be paying extra, ask exactly what you’re getting.

Can you specify a room in a particular area or level of the hotel ?

Outside rooms may be next to a busy street, highway or off-ramp.

Interior courtyard rooms are usually more expensive.  Poolside rooms, which can provide easy access and a nice view, can also be noisy.

Rooms located near restaurants, stairwells, elevators, ice machines or the lobby may be convenient, but are usually noisier.  Stay away from rooms above or next to a hotel’s bar or disco..

Ground floor rooms are easy to break into. On the other hand, upper level rooms may be too high in case of fire or other emergency.

Rooms with balconies may be dangerous if you have small children.  Consider a ground level room and just make sure it is secure.